Methylmercury and the Developing Brain

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[Selenium deficiency and brain functions: the significance for methylmercury toxicity].

Selenium has been long recognized as one of the essential trace elements. Although many selenoproteins have been identified in the last decade, the physiological roles of Se and selenoproteins remain to be elucidated. Since iodothyronine deiodinases (DIs), which regulate the tissue levels of thyroid hormone, are (likely to be) selenoproteins, Se might have specific roles for developing brain. I...

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Methylmercury elicits rapid inhibition of cell proliferation in the developing brain and decreases cell cycle regulator, cyclin E.

The developing brain is highly sensitive to methylmercury (MeHg). Still, the initial changes in cell proliferation that may contribute to long-term MeHg effects are largely undefined. Our previous studies with growth factors indicate that acute alterations of the G1/S-phase transition can permanently affect cell numbers and organ size. Therefore, we determined whether an environmental toxicant ...

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Estradiol and the developing brain.

Estradiol is the most potent and ubiquitous member of a class of steroid hormones called estrogens. Fetuses and newborns are exposed to estradiol derived from their mother, their own gonads, and synthesized locally in their brains. Receptors for estradiol are nuclear transcription factors that regulate gene expression but also have actions at the membrane, including activation of signal transdu...

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The vulnerable developing brain.

D uring healthy pregnancy, appropriate levels of fetal nutrition and oxygenation are indispensable for the optimal growth and development of the fetal organs. In pregnancy complicated by decreased nutrient and oxygen delivery to the fetus, current dogma is that the growth and development of key organs, such as the brain, are “spared” at the expense of nonessential organs served by peripheral va...

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ژورنال

عنوان ژورنال: Environmental Health Perspectives

سال: 2007

ISSN: 0091-6765,1552-9924

DOI: 10.1289/ehp.10302